Gene: Cardiovascular Disease

Source: Gene for cardiovascular disease, 27-03-2007

Geneticists collaborating at several universities in the US and the UK have discovered a gene that may put individuals at higher risk of developing cardiovascular disease. The identification of the gene, called kalirin, could lead to a test for assessing patients’ heart disease risk, says a report in the American Journal of Human Genetics (April). The research was sponsored by the US National Institutes of Health.

More details from this article:

Researchers at Duke University have identified a new gene that appears to put individuals at greater risk of developing cardiovascular disease. The gene, known as kalirin (KALRN), is located in chromosome 3 in a region that has been previously implicated in the development of coronary artery disease (CAD).

“We used an iterative approach to find a genetic association of kalirin with CAD,” investigator Dr Simon Gregory (Duke University Medical Center, Durham, NC) told heartwire. “The approach involved testing an increasing density of genetic markers from a previous linkage region on 3q13-21 within a population of unrelated case-control individuals. Markers that showed suggestive significance within the first CAD population were then typed in a second case-control population to establish replication of the initial results. Statistical analysis showed that kalirin was associated with CAD, particularly within individuals with early-onset CAD.”

The results of the study, led by Dr Liyong Wang (Duke University Medical Center), are published in the April 2007 issue of the American Journal of Human Genetics.

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