Gene: Cardiovascular Disease

Source: Gene for cardiovascular disease, 27-03-2007

Geneticists collaborating at several universities in the US and the UK have discovered a gene that may put individuals at higher risk of developing cardiovascular disease. The identification of the gene, called kalirin, could lead to a test for assessing patients’ heart disease risk, says a report in the American Journal of Human Genetics (April). The research was sponsored by the US National Institutes of Health.

More details from this article:

Researchers at Duke University have identified a new gene that appears to put individuals at greater risk of developing cardiovascular disease. The gene, known as kalirin (KALRN), is located in chromosome 3 in a region that has been previously implicated in the development of coronary artery disease (CAD).

“We used an iterative approach to find a genetic association of kalirin with CAD,” investigator Dr Simon Gregory (Duke University Medical Center, Durham, NC) told heartwire. “The approach involved testing an increasing density of genetic markers from a previous linkage region on 3q13-21 within a population of unrelated case-control individuals. Markers that showed suggestive significance within the first CAD population were then typed in a second case-control population to establish replication of the initial results. Statistical analysis showed that kalirin was associated with CAD, particularly within individuals with early-onset CAD.”

The results of the study, led by Dr Liyong Wang (Duke University Medical Center), are published in the April 2007 issue of the American Journal of Human Genetics.

Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s

%d bloggers like this: